Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.3
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 lozenge
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
50 mg
56%
Folate
667 mcg DFE (400 mcg folic acid)
167%
Vitamin B12 (as methylcobalamin)
3,000 mcg
125,000%
Top Medical Research Studies
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
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9
We aimed to explore the effects of folinic acid, also known as leucovorin, on patients suffering from chronic fatigue syndrome (CFS). Our investigation revealed some fascinating findings about this often misunderstood condition, particularly the links to immune response and Epstein-Barr virus (EBV) infection.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
Read More
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
Most Useful Reviews
9
Effective energy boost
4 people found this helpful
Great Energy Booster I have fibromyalgia and suffer from severe chronic fatigue syndrome. I have taken the equivalent mcg from other manufacturers, but this is the one that truly provides me with an energy boost. I never want to run out of it!
Read More
7.5
Inconsistent energy increase
1 people found this helpful
Superior Oral Methyl B12 I was diagnosed with Stage 3 adrenal fatigue and undermethylation. These work reasonably well, but I do not have a consistent experience, which may be personal. When I take 1-2 a day, the second one seems to have a greater effect. In the first week, I observed a significant increase in cognitive ability and physical energy. They work better for me when taken after 11.30 am rather than earlier in the morning. I haven't tried other brands yet, but I plan to compare.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.3
- All Researches
9
We aimed to explore the effects of folinic acid, also known as leucovorin, on patients suffering from chronic fatigue syndrome (CFS). Our investigation revealed some fascinating findings about this often misunderstood condition, particularly the links to immune response and Epstein-Barr virus (EBV) infection.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
In our evaluation of 58 CFS patients, we discovered that nearly all had previously been exposed to EBV, with a striking 72% showing signs of active reactivation. Additionally, an overwhelming 94% were found to have a severe B-cell immunodeficiency, evidenced by a marked reduction in their CD19+IgM+ mature B-lymphocyte population.
What stood out was that after treatment with folinic acid, an impressive 81% of the participants reported experiencing a noticeable improvement in their symptoms. This suggests that folinic acid might play a significant role in the management of CFS, particularly for those struggling with related immune deficiencies and EBV responses.
Our findings bring new insights into CFS, indicating that it may be a condition responding well to folinic acid treatment. This opens up exciting avenues for further research into effective therapies for those affected by this challenging syndrome.
Read More
8
We investigated the use of vitamin B12 nasal drops in adults with chronic fatigue syndrome (CFS) over three months. A total of 51 patients participated, and we measured their vitamin B12 levels alongside physical activity and fatigue scores.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Remarkably, two-thirds of the participants experienced positive results, including increased activity and better overall scores on fatigue measures. While responders showed significant improvements, the non-responders had only minor increases in vitamin B12 levels.
This indicates that vitamin B12 nasal drops could be a beneficial alternative to injections for many CFS patients.
Read More
8
We evaluated the impact of B12 injections combined with folic acid on patients with chronic fatigue syndrome, also known as myalgic encephalomyelitis (ME). In our survey of 38 patients, we identified two groups based on their response: Good and Mild responders. Good responders received more frequent and higher doses of B12, leading to significant improvements in their symptoms.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
However, Mild responders, many of whom took pain medications, reported minimal progress. Overall, while some patients showed benefits, the effectiveness of B12 treatment varies widely, and further research is needed to understand optimal dosages and drug interactions.
Read More
8
Folate improves fatigue-related disorders
We examined two groups of patients who exhibited neurological and psychiatric disorders responsive to folic acid treatment. The first group of seven individuals suffered from an acquired folate deficiency due to either poor absorption of nutrients or an inadequate diet. Their symptoms included significant fatigue, weight loss, and various neurological impairments. The second group, consisting of nine patients, presented idiopathic folate deficiency with chronic fatigue and family histories of restless legs syndrome.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Through neuropsychological testing, we observed abnormal intellectual functioning in all patients, along with issues highlighted on imaging studies like computerized transaxial tomography. Remarkably, after 6 to 12 months of folic acid therapy, a substantial improvement in their cognitive abilities and overall functioning was recorded.
This suggests that addressing folate deficiency might alleviate some aspects of fatigue and cognitive decline commonly associated with chronic fatigue syndrome. Our findings imply that long-term folate supplementation may lead to positive changes in those struggling with fatigue-related conditions, although the label of chronic fatigue syndrome was not explicitly used.
Read More
8
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective energy boost
4 people found this helpful
Great Energy Booster I have fibromyalgia and suffer from severe chronic fatigue syndrome. I have taken the equivalent mcg from other manufacturers, but this is the one that truly provides me with an energy boost. I never want to run out of it!
Read More
7.5
Inconsistent energy increase
1 people found this helpful
Superior Oral Methyl B12 I was diagnosed with Stage 3 adrenal fatigue and undermethylation. These work reasonably well, but I do not have a consistent experience, which may be personal. When I take 1-2 a day, the second one seems to have a greater effect. In the first week, I observed a significant increase in cognitive ability and physical energy. They work better for me when taken after 11.30 am rather than earlier in the morning. I haven't tried other brands yet, but I plan to compare.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. doi:10.3389/fphar.2019.01102
- Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648
- Lundell K, Qazi S, Eddy L, Uckun FM. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399.
- Jacobson W, Saich T, Borysiewicz LK, Behan WM, Behan PO, et al. Serum folate and chronic fatigue syndrome. Neurology. 1993;43:2645.
- Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989;149:2501.
- Botez MI, Fontaine F, Botez T, Bachevalier J. Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies. Eur Neurol. 1977;16:230.
- Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594.
- Devitt NF. Chronic fatigue syndrome. JAMA. 1998;279:432.
- Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301.
- Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.
- Demitrack MA, Engleberg NC. Chronic fatigue syndrome. Curr Ther Endocrinol Metab. 1994;5:135.
